2. A 54-year-old male experienced the onset of severe chest pain. An electrocardiogram demonstrated changes consistent with an acute myocardial infarction. He was given thrombolytic therapy with tissue plasminogen activator (tPA). However, his serum creatine kinase increased after this therapy. What is the most likely explanation for the enzyme activity increase?
3. A 51-year-old male has a blood pressure of 150/95 mm Hg. If this condition remains untreated for years, which cellular alterations may occur in the heart?
4. A 38-year-old woman experienced severe abdominal pain with hypotension and shock that led to her death within 36 hours. At autopsy fat necrosis was found in the mesentery. What is the most likely disease condition in this patient?
5. Absorption of radiant energy, such as x-rays, can result in cell injury. What are the cellular mechanisms that may protect against this injury?
6. A 32-year-old male experiences “heartburn” with substernal pain from reflux of gastric contents into the lower esophagus. After many months, a biopsy shows changes in the esophageal epithelium. What pathologic alterations may have occurred?
7. A young patient is admitted to the Emergency Room 24h after ingesting 15g of acetaminophen. The patient is treated with N-acetyl-cysteine (NAC) and recovers. Why was NAC given?
8. A young adult male patient is admitted to the Emergency Room 96h after ingesting 15g of acetaminophen. The ER doctors decide that treatment with NAC is not appropriate. Why?
9. In a chronic alcoholic would the effects of 1) meprobamate (a tranquilizer) and 2) acetaminophen be increased or decreased?
10. What is the relationship between the Bcl-2 gene, a gene that can prevent apoptosis, and follicular B-cell lymphomas with chomosome translocation?